Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23272041 | 1.00 | HSD17B10 (0.33) | HSD17B10TDP1KMORECQLCA12 | |
| SCHEMBL3672243 | 0.77 | CA12 (0.34) | KMOCA12BRD4BRPF1CA9 | |
| SCHEMBL28319074 | 0.77 | CA12 (0.34) | HSD17B10TDP1KMORECQLCA12 | |
| SCHEMBL11868257 | 0.76 | HDAC1 (0.37) | TDP1HDAC1HDAC6HDAC8 | |
| SCHEMBL29570632 | 0.75 | KDM4E (0.40) | TDP1KDM4EDAOMAPT | |
| SCHEMBL3672244 | 0.74 | PLK1 (0.41) | TDP1KMORECQLHDAC1HDAC6 | |
| SCHEMBL8229991 | 0.73 | CA12 (0.52) | HSD17B10KMOCA12BRD4BRPF1 | |
| SCHEMBL7738629 | 0.73 | NOS2 (0.38) | TDP1KMORECQLCA12BRD4 | |
| SCHEMBL30738537 | 0.73 | CA12 (0.34) | HSD17B10TDP1KMORECQLCA12 | |
| SCHEMBL7613241 | 0.73 | KDM4E (0.43) | KMORECQLCA12BRD4BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076667-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |