Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 5/20 | 0.45 |
| ▸ | PPARA | Q07869 | 5/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | QDPR | P09417 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29650110 | 0.88 | LMNA (0.47) | CNR1HRH2HRH1LMNAMAPT | |
| SCHEMBL14144348 | 0.88 | ALDH1A1 (0.54) | CNR1LMNAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL29684579 | 0.80 | SMN1; SMN2 (0.40) | HRH2HRH1LMNAMAPTPOLB | |
| SCHEMBL8369432 | 0.79 | NPC1 (0.48) | LMNAMAPTHTTSMN1; SMN2KDM4E | |
| SCHEMBL30711543 | 0.79 | QDPR (0.47) | HRH2HRH1LMNAMAPTHTT | |
| SCHEMBL29742123 | 0.79 | HRH2 (0.41) | HRH2HRH1LMNAMAPTPOLB | |
| SCHEMBL29733157 | 0.78 | SMYD3 (0.40) | HRH2HRH1PPARGPPARALMNA | |
| SCHEMBL8259131 | 0.78 | SMN1; SMN2 (0.50) | HRH2HRH1LMNAMAPTPOLB | |
| SCHEMBL652961 | 0.77 | NAMPT (0.60) | CNR1CCR1 | |
| SCHEMBL5460918 | 0.77 | CYP1A2 (0.43) | HRH2HRH1LMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |