Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.36 |
| ▸ | USP8 | P40818 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16080223 | 1.00 | TRPV4 (0.46) | TRPV4MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL12777966 | 0.85 | TRPV4 (0.42) | TRPV4MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL1556216 | 0.83 | TDO2 (0.43) | TRPV4MEN1KMT2ATDO2PTGES2 | |
| SCHEMBL26598944 | 0.81 | CA12 (0.46) | MEN1KMT2AHTR2AHTR2CKCNH2 | |
| SCHEMBL29212553 | 0.81 | EPAS1 (0.44) | MEN1KMT2AHTR2AHTR2CKCNH2 | |
| SCHEMBL7765655 | 0.79 | TRPV4 (0.60) | TRPV4SLC22A12PTGES2 | |
| SCHEMBL19682467 | 0.79 | TRPV4 (0.49) | TRPV4MEN1KMT2ASLC22A12 | |
| SCHEMBL28069903 | 0.79 | EPAS1 (0.44) | EPAS1 | |
| SCHEMBL711705 | 0.78 | TRPV4 (0.42) | TRPV4SLC22A12 | |
| SCHEMBL19682468 | 0.78 | TRPV4 (0.43) | TRPV4SLC22A12USP8USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |
| EP-4061124-A1 | TRPV4 RECEPTOR LIGANDS | University of Utah Research Foundation (US) | 2022-09-28 | — | — | EP | disclosed |