⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296923 | 0.77 | — | — | |
| SCHEMBL5515691 | 0.77 | — | — | |
| SCHEMBL616487 | 0.75 | — | — | |
| SCHEMBL17472748 | 0.75 | TSHR (0.35) | — | |
| Urea SCHEMBL28964422 | 0.72 | ALDH1A1 (0.36) | — | |
| SCHEMBL14405864 | 0.70 | ALDH1A1 (0.31) | — | |
| SCHEMBL14738100 | 0.70 | — | — | |
| SCHEMBL7354265 | 0.69 | — | — | |
| SCHEMBL28687915 | 0.67 | — | — | |
| SCHEMBL21786772 | 0.67 | LMNA (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572374-B2 | N-cyano-7-azanorbornane derivatives and uses thereof | AMGEN INC. (US) | 2023-02-07 | — | — | US | disclosed |
| US-20220363694-A1 | N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF | AMGEN INC. (US) | 2022-11-17 | — | — | US | disclosed |