SCHEMBL29951097

SCHEMBL29951097

[C-]#[N+]C(c1cccc([N+](=O)[O-])c1)S(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.48
KMT2A Q03164 3/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C19 P33261 1/20 0.47
TSHR P16473 2/20 0.46
ACHE P22303 2/20 0.46
NFE2L2 Q16236 1/20 0.45
ALDH1A1 P00352 2/20 0.44
LMNA P02545 2/20 0.44
GAA P10253 2/20 0.44
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
KMO O15229 1/20 0.42
MEN1 O00255 1/20 0.42
HPGD P15428 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
CA2 P00918 1/20 0.42
CA5A P35218 1/20 0.42
POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29954856 0.83 ACHE (0.53) KMT2AACHEALDH1A1GAAMAPT
SCHEMBL5837673 0.83 HTT (0.41) HTTKMT2AALDH1A1GAAMAPT
SCHEMBL4473496 0.80 NPY2R (0.36) HTTACHEGAAMAPTL3MBTL1
SCHEMBL29952039 0.80 MAPT (0.44) KMT2ACYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL30716693 0.80 CES2 (0.37) ACHENFE2L2ALDH1A1HPGDCA2
SCHEMBL4833791 0.80 CES2 (0.37) ACHENFE2L2ALDH1A1HPGDCA2
SCHEMBL5851624 0.80 MAPT (0.44) KMT2ACYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL571272 0.80 EGFR (0.40) KMT2AALDH1A1LMNAGAAMAPT
SCHEMBL408195 0.78 NPY2R (0.47) HTTKMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL7931633 0.78 HTT (0.47) HTTKMT2ACYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed