Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3319716 | 1.00 | ENPP2 (0.33) | ENPP2P2RX7TNFRIPK1ADRA2A | |
| SCHEMBL29956143 | 0.82 | TNF (0.39) | ENPP2TNFRIPK1 | |
| SCHEMBL5422266 | 0.78 | ALDH1A1 (0.42) | ENPP2CLCN2CYP3A4 | |
| SCHEMBL29955010 | 0.78 | TNF (0.36) | ENPP2TNFRIPK1CYP3A4 | |
| SCHEMBL15609444 | 0.78 | ACHE (0.32) | ACHE | |
| SCHEMBL29952822 | 0.78 | ALDH1A1 (0.42) | ENPP2CLCN2CYP3A4 | |
| SCHEMBL28136581 | 0.78 | ACHE (0.32) | ACHE | |
| SCHEMBL21543102 | 0.77 | ALDH1A1 (0.37) | ACHE | |
| SCHEMBL29955796 | 0.77 | MAPK1 (0.39) | ENPP2TNFRIPK1CYP3A4 | |
| SCHEMBL29491113 | 0.77 | ALDH1A1 (0.37) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499612-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2025-02-05 | — | — | EP | disclosed |
| CN-118974020-A | Substituted 3-aminoindazole derivatives as kinase inhibitors | 内尔维亚诺医疗科学公司 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |