Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340525 | 1.00 | ENPP2 (0.41) | ENPP2TTRALDH1A1NPSR1KMT2A | |
| SCHEMBL25379067 | 0.80 | TTR (0.39) | ENPP2TTR | |
| SCHEMBL29951314 | 0.78 | CHRNB2 (0.33) | ENPP2ALDH1A1 | |
| SCHEMBL29953155 | 0.78 | PIK3CD (0.43) | ENPP2TTRALDH1A1 | |
| SCHEMBL30858247 | 0.78 | CHRNB2 (0.39) | ENPP2TTR | |
| SCHEMBL393995 | 0.78 | CHRNB2 (0.33) | ENPP2ALDH1A1 | |
| SCHEMBL16113231 | 0.78 | CHRNB2 (0.39) | ENPP2TTR | |
| SCHEMBL14121768 | 0.78 | KEAP1 (0.33) | ENPP2TTR | |
| SCHEMBL29955519 | 0.78 | KEAP1 (0.33) | ENPP2TTR | |
| SCHEMBL16734509 | 0.78 | PIK3CD (0.43) | ENPP2TTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478131-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116478132-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-109983001-B | 2, 5-disubstituted 3-methylpyrazines and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |