Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4268830 | 1.00 | TDP1 (0.61) | TDP1ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL8035343 | 0.84 | TDP1 (0.53) | TDP1ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL7689361 | 0.82 | ALDH1A1 (0.50) | TDP1ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL12402952 | 0.79 | GABRA1 (0.45) | TDP1ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL8073452 | 0.79 | TDP1 (0.69) | TDP1ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL28987874 | 0.79 | TDP1 (0.48) | TDP1ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL9304607 | 0.79 | GABRA1 (0.52) | TDP1ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL2888296 | 0.78 | ERN1 (0.52) | TDP1ALDH1A1KDM4EGAASRC | |
| SCHEMBL15280203 | 0.77 | GABRA1 (0.50) | TDP1ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL139560 | 0.77 | GABRA1 (0.50) | TDP1ALDH1A1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4634173-A1 | NEW SUBSTITUTED INDOLE-2-CARBOXAMIDES AS PHGDH INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2025-10-22 | — | — | EP | disclosed |
| EP-4482831-A1 | NOVEL BICYCLIC COMPOUNDS AS RAD51 INHIBITORS | Satya Therapeutics, Inc. (US) | 2025-01-01 | — | — | EP | disclosed |
| WO-2024126453-A1 | NEW SUBSTITUTED INDOLE-2-CARBOXAMIDES AS PHGDH INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-06-20 | — | — | WO | disclosed |
| WO-2023161782-A1 | NOVEL BICYCLIC COMPOUNDS AS RAD51 INHIBITORS | SATYARX PHARMA INNOVATIONS PVT LTD (IN) | 2023-08-31 | — | — | WO | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |