Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.52 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15330140 | 0.90 | NPC1 (0.53) | NPC1RAB9AF10AKR1B10AKR1B1 | |
| SCHEMBL29951720 | 0.86 | NPC1 (0.67) | NPC1RAB9AMIFMAOBMGLL | |
| SCHEMBL29952583 | 0.86 | RAB9A (0.52) | NPC1RAB9AMIFMAOBMGLL | |
| SCHEMBL29956922 | 0.86 | NPC1 (0.52) | NPC1RAB9AMIFMAOBMGLL | |
| SCHEMBL23452687 | 0.86 | RAB9A (0.52) | NPC1RAB9AMIFMAOBMGLL | |
| SCHEMBL4372681 | 0.85 | NPC1 (0.60) | NPC1RAB9AF10MIFMAOB | |
| SCHEMBL29950865 | 0.84 | NPC1 (0.53) | NPC1RAB9ATTRMAOBMGLL | |
| SCHEMBL29951111 | 0.83 | NPC1 (0.52) | NPC1RAB9AMIFMAOBMGLL | |
| SCHEMBL29953440 | 0.83 | RAB9A (0.52) | NPC1RAB9AMIFMAOBMGLL | |
| SCHEMBL13529179 | 0.81 | CASP3 (0.56) | NPC1RAB9AF10MAOBMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |