Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322950 | 1.00 | TDP1 (0.35) | TDP1ERN1PIK3CDSIRT6CYP1A2 | |
| SCHEMBL6856975 | 0.83 | ERN1 (0.34) | TDP1ERN1PIK3CDSIRT6CYP1A2 | |
| SCHEMBL23024893 | 0.79 | TDP1 (0.35) | TDP1PIK3CD | |
| SCHEMBL29037724 | 0.79 | TDP1 (0.35) | TDP1PIK3CD | |
| SCHEMBL5375502 | 0.78 | NOS3 (0.38) | TDP1 | |
| SCHEMBL899188 | 0.78 | TDP1 (0.45) | TDP1ERN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29411195 | 0.78 | TDP1 (0.45) | TDP1ERN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15873128 | 0.75 | TRIM24 (0.35) | ERN1 | |
| SCHEMBL29958162 | 0.75 | ERN1 (0.44) | ERN1 | |
| SCHEMBL15332623 | 0.75 | ERN1 (0.41) | TDP1ERN1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119365458-A | Fused tricyclic compounds, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| EP-4294790-A1 | SMARCA DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| WO-2022178532-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-08-25 | — | — | WO | disclosed |