SCHEMBL29954582

SCHEMBL29954582

O=Cc1cc(F)cnc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 5/20 0.39
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
MPI P34949 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NFE2L2 Q16236 2/20 0.35
TDP1 Q9NUW8 1/20 0.33
AGBL2 Q5U5Z8 1/20 0.33
APLNR P35414 1/20 0.32
F2 P00734 1/20 0.32
PLAU P00749 1/20 0.32
KLKB1 P03952 1/20 0.32
ELANE P08246 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2119952 1.00 ERN1 (0.39) ERN1CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL23362656 0.79 AGBL2 (0.33) AGBL2
SCHEMBL18603197 0.79 AGBL2 (0.30) AGBL2
SCHEMBL2124954 0.79 ALDH1A1 (0.31) ALDH1A1AGBL2
SCHEMBL29954200 0.78 ERN1 (0.42) ERN1ALDH1A1KDM4EMAPTAGBL2
SCHEMBL30129411 0.78 ERN1 (0.46) ERN1CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL6076848 0.78 ERN1 (0.46) ERN1CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL29952839 0.77 CYP1A2 (0.39) ERN1CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8544546 0.77 CYP1A2 (0.39) ERN1CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL2851214 0.75 ALDH1A1 (0.47) ERN1CYP1A2CYP3A4CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed