Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.58 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.58 |
| ▸ | ABAT | P80404 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.49 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL572475 | 1.00 | ATM (0.60) | ATMTDP1VCAM1ALDH5A1ABAT | |
| SCHEMBL472686 | 0.85 | VCAM1 (0.62) | ATMTDP1VCAM1ALDH5A1ABAT | |
| SCHEMBL16958996 | 0.83 | TDP1 (0.58) | ATMTDP1VCAM1ALDH5A1ABAT | |
| SCHEMBL28128776 | 0.83 | TDP1 (0.58) | ATMTDP1VCAM1ALDH5A1ABAT | |
| SCHEMBL1546955 | 0.83 | TDP1 (0.58) | ATMTDP1VCAM1ALDH5A1ABAT | |
| SCHEMBL1466944 | 0.82 | ALDH5A1 (0.69) | VCAM1ALDH5A1ABATALDH1A1MAPT | |
| SCHEMBL31484716 | 0.82 | ALDH5A1 (0.69) | VCAM1ALDH5A1ABATALDH1A1MAPT | |
| SCHEMBL27110924 | 0.80 | ATM (0.55) | ATMTDP1VCAM1ALDH5A1ABAT | |
| SCHEMBL2296057 | 0.79 | CRHBP (0.57) | ATMTDP1ALDH5A1ABATALDH1A1 | |
| SCHEMBL2296058 | 0.79 | CRHBP (0.57) | ATMTDP1ALDH5A1ABATALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121043-A1 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |