Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29952031 | 1.00 | CYP19A1 (0.51) | CYP19A1TBXAS1PRKCZMELKCCNT1 | |
| SCHEMBL3126133 | 0.93 | CYP19A1 (0.51) | CYP19A1TBXAS1CCNT1CDK9HASPIN | |
| SCHEMBL29956130 | 0.93 | CYP19A1 (0.51) | CYP19A1TBXAS1CCNT1CDK9HASPIN | |
| SCHEMBL24343240 | 0.84 | CYP19A1 (0.50) | CYP19A1TBXAS1PRKCZMELKMRGPRX4 | |
| SCHEMBL29186057 | 0.80 | CYP19A1 (0.47) | CYP19A1TBXAS1PRKCZMELKCCNT1 | |
| SCHEMBL6897234 | 0.77 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKMRGPRX4 | |
| SCHEMBL30896286 | 0.77 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKCCNT1 | |
| SCHEMBL3153982 | 0.77 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKHASPIN | |
| SCHEMBL5779124 | 0.77 | MELK (0.55) | CYP19A1TBXAS1PRKCZMELKCYP2A6 | |
| SCHEMBL3821797 | 0.77 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383761-B1 | Phenyl- and pyridyl-piperidines with tnf activity | SANOFI AVENTIS (FR) | 2011-03-02 | — | — | EP | disclosed |
| US-7326720-B2 | Phenyl- and pyridylpiperidines with TNF activity | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| US-20050209216-A1 | Phenyl-and pyridyl-diazaheterocycles having a tnf-modulating activity | SANOFI-AVENTIS (FR) | 2005-09-22 | — | — | US | disclosed |
| EP-1517896-A2 | PHENYL- AND PYRIDYL-DIAZAHETEROCYCLES HAVING A TNF-MODULATING ACTIVITY | Sanofi-Aventis (FR) | 2005-03-30 | — | — | EP | disclosed |
| EP-1226137-B8 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI AVENTIS (FR) | 2004-12-15 | — | — | EP | disclosed |
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |
| CN-1158276-C | Phenyl-and pyridyl-tetrahydropyridines with TNF inhibiting activity | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-07-21 | — | — | CN | disclosed |
| US-20040127517-A1 | Phenyl-and pyridyl-piperidines with tnf activity | SANOFI-AVENTIS (FR) | 2004-07-01 | — | — | US | disclosed |
| EP-1383761-A1 | PHENYL- AND PYRIDYL-PIPERIDINES WITH TNF ACTIVITY | Sanofi-Aventis (FR) | 2004-01-28 | — | — | EP | disclosed |
| WO-2003106425-A2 | PHENYL- AND PYRIDYL-DIAZAHETEROCYCLES HAVING A TNF-MODULATING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2003-12-24 | — | — | WO | disclosed |
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |
| CN-1391570-A | Phenyl-and pyridyl-tetrahydro-pyridines having TNF inhibiting activity | SANOFI SYNTHELABO (FR) | 2003-01-15 | — | — | CN | disclosed |
| WO-2002085887-A1 | PHENYL- AND PYRIDYL-PIPERIDINES WITH TNF ACTIVITY | SANOFI-SYNTHELABO (FR) | 2002-10-31 | — | — | WO | disclosed |
| EP-1226137-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2002-07-31 | — | — | EP | disclosed |
| EP-1189879-A1 | INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001029026-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2001-04-26 | — | — | WO | disclosed |
| WO-2000071512-A1 | INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2000-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127517-A1 | Phenyl-and pyridyl-piperidines with tnf activity | TNF, TNFRSF1A, NGFR | CYP19A1 2646/4885TBXAS1 846/4885PRKCZ 1425/4885 |
| US-20050209216-A1 | Phenyl-and pyridyl-diazaheterocycles having a tnf-modulating activity | TNF, TNFRSF1A, CD40 | CYP19A1 773/4885TBXAS1 1078/4885PRKCZ 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.