SCHEMBL29956479

SCHEMBL29956479

Cc1cccc(C(F)(F)F)c1B(O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
MGLL Q99685 2/20 0.37
SCN8A Q9UQD0 1/20 0.37
AR P10275 3/20 0.36
ATM Q13315 2/20 0.35
TRPA1 O75762 1/20 0.35
ALDH1A1 P00352 4/20 0.35
TDP1 Q9NUW8 2/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
POLB P06746 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HSD11B1 P28845 2/20 0.34
TAS2R14 Q9NYV8 1/20 0.34
ALOX12 P18054 1/20 0.34
P2RX7 Q99572 1/20 0.33
CA2 P00918 1/20 0.32
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3783762 0.85 MGLL (0.43) MGLLALDH1A1TDP1KDM4EGAA
SCHEMBL1396708 0.82 MGLL (0.38) MGLLSCN8AALDH1A1TDP1GAA
SCHEMBL24425048 0.80 CA2 (0.45) GABRA1GABRB2MGLLALDH1A1TDP1
SCHEMBL61913 0.80 ALDH1A1 (0.50) GABRA1GABRB2ATMTRPA1ALDH1A1
SCHEMBL3743971 0.79 MGLL (0.39) MGLLTRPA1ALDH1A1TDP1KDM4E
SCHEMBL29950925 0.79 MGLL (0.39) MGLLTRPA1ALDH1A1TDP1KDM4E
SCHEMBL13160060 0.78 AR (0.33) MGLLARHSD11B1TAS2R14
SCHEMBL20694978 0.78 ALDH1A1 (0.48) GABRA1GABRB2ATMTRPA1ALDH1A1
SCHEMBL28221318 0.78 ALDH1A1 (0.48) GABRA1GABRB2ATMTRPA1ALDH1A1
SCHEMBL23273035 0.78 MGLL (0.38) MGLLARATMTRPA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed