Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29952656 | 0.87 | HTT (0.36) | ENPP2HTTSMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL15010805 | 0.87 | HTT (0.36) | ENPP2HTTSMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL29956725 | 0.85 | ENPP2 (0.39) | ENPP2KCNH2KMT2AALDH1A1MAPT | |
| SCHEMBL2462591 | 0.85 | ENPP2 (0.39) | ENPP2KCNH2KMT2AALDH1A1MAPT | |
| SCHEMBL14746822 | 0.80 | ENPP2 (0.57) | ENPP2HTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL29550601 | 0.80 | ENPP2 (0.57) | ENPP2HTTSMN1; SMN2KMT2AMAPT | |
| SCHEMBL29469117 | 0.80 | ENPP2 (0.57) | ENPP2HTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL520857 | 0.80 | ENPP2 (0.57) | ENPP2HTTSMN1; SMN2KMT2AMAPT | |
| SCHEMBL12098298 | 0.78 | ENPP2 (0.55) | ENPP2HTTSMN1; SMN2KMT2AMAPT | |
| SCHEMBL20639120 | 0.76 | CA3 (0.41) | HTTSMN1; SMN2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |