Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956109 | 0.96 | KDM4E (0.50) | KDM4EALDH1A1TSHRSIGMAR1CASP6 | |
| SCHEMBL2562021 | 0.84 | KDM4E (0.37) | KDM4EALDH1A1TSHRSIGMAR1KMT2A | |
| SCHEMBL29955444 | 0.84 | KDM4E (0.59) | KDM4EALDH1A1TSHRSIGMAR1CASP6 | |
| SCHEMBL15330412 | 0.84 | KDM4E (0.37) | KDM4EALDH1A1SIGMAR1KMT2AATM | |
| SCHEMBL29957401 | 0.81 | ALDH1A1 (0.38) | KDM4EALDH1A1SIGMAR1GAAKMT2A | |
| SCHEMBL2559874 | 0.81 | KDM4E (0.35) | KDM4EALDH1A1SIGMAR1GAAHTT | |
| SCHEMBL29952380 | 0.81 | KDM4E (0.35) | KDM4EALDH1A1SIGMAR1ATMLMNA | |
| SCHEMBL15332186 | 0.80 | SIGMAR1 (0.37) | KDM4EALDH1A1SIGMAR1GAAEPHX1 | |
| SCHEMBL2559097 | 0.78 | KDM4E (0.36) | KDM4ESIGMAR1GAAHTTCYP2C9 | |
| SCHEMBL2556245 | 0.78 | SIGMAR1 (0.41) | KDM4EALDH1A1SIGMAR1EPHX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |