SCHEMBL29957656

SCHEMBL29957656

COc1ccnc2c(C=O)c[nH]c12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41
CCR1 P32246 1/20 0.40
CCR5 P51681 1/20 0.40
CCR8 P51685 1/20 0.40
KMT2A Q03164 3/20 0.39
KDM4E B2RXH2 2/20 0.38
MAPT P10636 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
TRIM24 O15164 1/20 0.37
TRIM33 Q9UPN9 1/20 0.37
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ERN1 O75460 4/20 0.37
DYRK1A Q13627 2/20 0.36
NFATC1 O95644 1/20 0.36
GSK3B P49841 1/20 0.36
TLR2 O60603 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13132297 0.79 TRIM24 (0.51) ALDH1A1CYP1A2CYP2C19CCR1CCR5
SCHEMBL13909686 0.77 KDM5A (0.45) CCR1CCR5CCR8KMT2AKDM4E
SCHEMBL13903457 0.77 DYRK1A (0.46) ALDH1A1KMT2AKDM4EMAPTTDP1
SCHEMBL29950704 0.76 CCR1 (0.43) ALDH1A1CYP1A2CYP2C19CCR1CCR5
SCHEMBL16593253 0.76 DYRK1A (0.42) DYRK1ANFATC1GSK3B
SCHEMBL29951570 0.76 CCR1 (0.43) ALDH1A1CYP1A2CYP2C19CCR1CCR5
SCHEMBL29951249 0.75 CCNT1 (0.51) ALDH1A1CYP1A2CYP2C19KMT2AKDM4E
SCHEMBL7837750 0.73 ALDH1A1 (0.45) ALDH1A1CYP1A2CYP2C19KMT2AKDM4E
SCHEMBL29954432 0.73 ALDH1A1 (0.45) ALDH1A1CYP1A2CYP2C19KMT2AKDM4E
SCHEMBL13691931 0.73 PDPK1 (0.44) ALDH1A1CYP1A2CYP2C19KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed