Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GRN | P28799 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13248452 | 0.91 | ALOX5AP (0.49) | GPR132ALOX5APPARP10MAPK14SMO | |
| SCHEMBL2999279 | 0.85 | PARP10 (0.57) | ALOX5APPARP10MAPK14SMOALDH1A1 | |
| SCHEMBL3000832 | 0.85 | ALOX5AP (0.56) | ALOX5APPARP10ADAMTS4MAPK14SMO | |
| SCHEMBL13267977 | 0.84 | ALOX5AP (0.51) | GPR132ALOX5APPARP10MAPK14SMO | |
| SCHEMBL14642563 | 0.83 | ALOX5AP (0.47) | ALOX5APPARP10ADAMTS4MAPK14SMO | |
| SCHEMBL14008636 | 0.83 | ALOX5AP (0.53) | ALOX5APPARP10ADAMTS4MAPK14SMO | |
| SCHEMBL2248223 | 0.83 | ALOX5AP (0.55) | ALOX5APPARP10ADAMTS4MAPK14SMO | |
| SCHEMBL3000149 | 0.82 | ALOX5AP (0.56) | ALOX5APPARP10ADAMTS4MAPK14SMO | |
| SCHEMBL3000321 | 0.81 | ALOX5AP (0.52) | ALOX5APPARP10MAPK14SMOSMN1; SMN2 | |
| SCHEMBL2993311 | 0.80 | ALOX5AP (0.51) | ALOX5APPARP10MAPK14SMOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| WO-2008156721-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | GPR132 540/4885ALOX5AP 15/4885PARP10 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.