Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143014 | 1.00 | KMO (0.55) | KMOMCL1TDP1LMNAL3MBTL1 | |
| SCHEMBL30711650 | 0.95 | KMO (0.56) | KMOMCL1TDP1LMNAL3MBTL1 | |
| SCHEMBL29174301 | 0.95 | KMO (0.56) | KMOMCL1TDP1LMNAL3MBTL1 | |
| SCHEMBL20037218 | 0.89 | TDP1 (0.53) | TDP1LMNAL3MBTL1HTTUSP2 | |
| SCHEMBL3871316 | 0.84 | MCL1 (0.47) | MCL1LMNAL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL29174300 | 0.84 | KMO (0.44) | KMOMCL1TDP1LMNAL3MBTL1 | |
| SCHEMBL2873285 | 0.83 | MCL1 (0.43) | MCL1LMNAL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL10203771 | 0.81 | KMO (0.58) | KMOMCL1ALDH1A1HSD17B10NPY5R | |
| SCHEMBL31306259 | 0.80 | TNF (0.51) | TDP1LMNAHTTUSP2ALDH1A1 | |
| SCHEMBL3864912 | 0.80 | KMT2A (0.61) | LMNAL3MBTL1ALDH1A1TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |