Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006476 | 1.00 | KMO (0.61) | KMOKMT2AOXER1NPY5RHTR7 | |
| SCHEMBL29174329 | 0.94 | KMO (0.63) | KMOKMT2AOXER1NPY5RHTR7 | |
| SCHEMBL2006946 | 0.87 | HTR2A (0.55) | KMOKMT2AOXER1NPY5RLMNA | |
| SCHEMBL1576364 | 0.85 | KMO (0.72) | KMOKMT2AOXER1NPY5RHTR7 | |
| SCHEMBL29957878 | 0.85 | KMO (0.72) | KMOKMT2AOXER1NPY5RHTR7 | |
| SCHEMBL3353214 | 0.82 | LMNA (0.44) | KMOKMT2ALMNAHTR2AHTR2C | |
| SCHEMBL10203771 | 0.81 | KMO (0.58) | KMOKMT2AOXER1NPY5RHTR7 | |
| SCHEMBL31177216 | 0.81 | HTR2C (0.55) | KMOKMT2ANPY5RHTR7LMNA | |
| SCHEMBL10165545 | 0.80 | KMO (0.57) | KMOKMT2AOXER1NPY5RHTR7 | |
| SCHEMBL24414633 | 0.79 | LMNA (0.42) | KMOKMT2ALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |