Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 6/20 | 0.42 |
| ▸ | NOS1 | P29475 | 6/20 | 0.42 |
| ▸ | NOS2 | P35228 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033421 | 1.00 | MAPT (0.46) | MAPTKDM4EGAACYP1A2GLA | |
| SCHEMBL28068640 | 0.88 | HPGD (0.45) | MAPTKDM4EGAACYP1A2GLA | |
| SCHEMBL29174264 | 0.82 | ADRA1D (0.35) | MAPTKDM4EGAACYP1A2GLA | |
| SCHEMBL25244289 | 0.82 | KDM4E (0.46) | MAPTKDM4EGAACYP1A2GLA | |
| SCHEMBL30711675 | 0.81 | ADRA1D (0.47) | MAPTCYP2C9ADRA1DF2NOS3 | |
| SCHEMBL27033537 | 0.81 | ADRA1D (0.47) | MAPTCYP2C9ADRA1DF2NOS3 | |
| SCHEMBL27033816 | 0.80 | ADRA1D (0.52) | ADRA1DF2NOS3NOS1NOS2 | |
| SCHEMBL30711627 | 0.80 | ADRA1D (0.52) | ADRA1DF2NOS3NOS1NOS2 | |
| SCHEMBL7133160 | 0.79 | MAPT (0.49) | MAPTKDM4EGAACYP1A2CYP3A4 | |
| Lithium Ion SCHEMBL29174263 | 0.78 | ADRA1D (0.45) | MAPTCYP2C9ADRA1DF2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |