Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.33 |
| ▸ | WNT3A | P56704 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299138 | 0.86 | PTGS2 (0.35) | NR3C1PTGS2SYKCHRNA7CYP19A1 | |
| SCHEMBL299025 | 0.78 | TRPV1 (0.46) | — | |
| SCHEMBL297590 | 0.66 | TRPV1 (0.56) | — | |
| SCHEMBL299097 | 0.64 | TRPV1 (0.44) | — | |
| SCHEMBL30795530 | 0.60 | PTGS2 (0.49) | NR3C1PTGS2CTNNB1WNT3ASLC6A2 | |
| SCHEMBL3428521 | 0.59 | NPC1 (0.56) | PTGS2CTNNB1WNT3ASLC6A2SLC6A4 | |
| SCHEMBL5496056 | 0.59 | SLC6A2 (0.55) | NR3C1PTGS2CTNNB1WNT3AFYN | |
| SCHEMBL6263511 | 0.58 | PTGS2 (0.78) | PTGS2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8869741 | 0.58 | PDE10A (0.44) | PTGS2CTNNB1WNT3ASLC6A2SLC6A4 | |
| SCHEMBL3425528 | 0.57 | ABL1 (0.42) | NR3C1PTGS2SYKCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427436-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-03-14 | — | — | EP | claimed |
| WO-2010127855-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2010-11-11 | — | — | WO | claimed |