Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.30 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299609 | 0.86 | NR3C1 (0.36) | PTGS2NR3C1CYP19A1SYKCHRNA7 | |
| SCHEMBL299097 | 0.77 | TRPV1 (0.44) | — | |
| SCHEMBL299025 | 0.64 | TRPV1 (0.46) | — | |
| SCHEMBL30795530 | 0.62 | PTGS2 (0.49) | PTGS2NR3C1SYK | |
| SCHEMBL6263511 | 0.60 | PTGS2 (0.78) | PTGS2 | |
| SCHEMBL18393143 | 0.60 | MAOA (0.43) | PTGS2BRAF | |
| SCHEMBL4302181 | 0.59 | ABL1 (0.41) | PTGS2 | |
| SCHEMBL3425528 | 0.59 | ABL1 (0.42) | PTGS2NR3C1SYKCHRNA7 | |
| SCHEMBL30795579 | 0.58 | PTGS2 (0.48) | PTGS2 | |
| SCHEMBL27667144 | 0.58 | PTGS2 (0.61) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427436-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-03-14 | — | — | EP | claimed |
| WO-2010127855-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2010-11-11 | — | — | WO | claimed |