Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18742219 | 0.84 | LMNA (0.51) | CSNK2A2CSNK2A1LMNAADORA2BHDAC6 | |
| Hydrochloric Acid SCHEMBL18742227 | 0.83 | LMNA (0.50) | CSNK2A2CSNK2A1LMNAADORA2BHDAC6 | |
| SCHEMBL24750355 | 0.82 | F2 (0.38) | CSNK2A2CSNK2A1LMNAHDAC6KDM4E | |
| SCHEMBL24750385 | 0.72 | POLB (0.50) | TDP1POLB | |
| SCHEMBL24750405 | 0.72 | LMNA (0.43) | LMNA | |
| SCHEMBL29966497 | 0.72 | LMNA (0.43) | LMNA | |
| SCHEMBL18704122 | 0.72 | ADORA2B (0.52) | CSNK2A2CSNK2A1LMNAADORA2BHDAC6 | |
| SCHEMBL18704235 | 0.71 | ADORA2B (0.49) | CSNK2A2CSNK2A1LMNAADORA2BHDAC6 | |
| SCHEMBL24750113 | 0.71 | BRD4 (0.42) | LMNAADORA2B | |
| Hydrochloric Acid SCHEMBL18742217 | 0.71 | ADORA2B (0.51) | CSNK2A2CSNK2A1LMNAADORA2BHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313988-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS | Orphagen Pharmaceuticals, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204481-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS | Orphagen Pharmaceuticals, Inc. (US) | 2022-09-29 | — | — | WO | disclosed |