Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24750405 | 1.00 | LMNA (0.43) | LMNAKMT2ARXFP1NPC1RAB9A | |
| SCHEMBL24750368 | 0.89 | LMNA (0.40) | LMNAKMT2ARXFP1NPC1RAB9A | |
| SCHEMBL24750376 | 0.81 | CCR2 (0.38) | LMNAKMT2ARXFP1ABL1 | |
| SCHEMBL29965144 | 0.81 | CCR2 (0.38) | LMNAKMT2ARXFP1ABL1 | |
| SCHEMBL24750365 | 0.81 | CCR2 (0.38) | LMNAKMT2ARXFP1ABL1 | |
| SCHEMBL24750658 | 0.80 | EPHX2 (0.37) | LMNAKMT2ARXFP1NPC1RAB9A | |
| SCHEMBL29965806 | 0.80 | EPHX2 (0.38) | LMNAKMT2ARXFP1NPC1RAB9A | |
| SCHEMBL24750382 | 0.80 | EPHX2 (0.37) | LMNAKMT2ARXFP1NPC1RAB9A | |
| SCHEMBL24750372 | 0.80 | EPHX2 (0.38) | LMNAKMT2ARXFP1NPC1RAB9A | |
| SCHEMBL29965867 | 0.80 | EPHX2 (0.37) | LMNAKMT2ARXFP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313988-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS | Orphagen Pharmaceuticals, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204481-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS | Orphagen Pharmaceuticals, Inc. (US) | 2022-09-29 | — | — | WO | disclosed |