Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.32 |
| ▸ | WDR5 | P61964 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29964665 | 1.00 | DGAT1 (0.37) | DGAT1ALOX5APFEN1BMPR1BBMPR1A | |
| SCHEMBL29964018 | 0.87 | LRRK2 (0.37) | DGAT1ALOX5APFEN1TGFBR1FFAR2 | |
| SCHEMBL29964621 | 0.87 | LRRK2 (0.37) | DGAT1ALOX5APFEN1TGFBR1FFAR2 | |
| SCHEMBL29964948 | 0.82 | DGAT1 (0.36) | DGAT1ALOX5APFEN1BMPR1BBMPR1A | |
| SCHEMBL29965063 | 0.82 | DGAT1 (0.36) | DGAT1ALOX5APFEN1BMPR1BBMPR1A | |
| SCHEMBL24680971 | 0.77 | RAD51 (0.43) | FFAR2NR1H2NR1H3 | |
| SCHEMBL24681541 | 0.77 | RAD51 (0.43) | FFAR2NR1H2NR1H3 | |
| SCHEMBL29914426 | 0.77 | RAD51 (0.43) | FFAR2NR1H2NR1H3 | |
| SCHEMBL24680805 | 0.77 | RAD51 (0.43) | FFAR2NR1H2NR1H3 | |
| SCHEMBL29914582 | 0.77 | RAD51 (0.43) | FFAR2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | DGAT1 3546/4885ALOX5AP 4225/4885FEN1 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.