Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 6/20 | 0.46 |
| ▸ | THRA | P10827 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23663084 | 1.00 | POLB (0.52) | POLBKDM4ETHRBTHRAALDH1A1 | |
| SCHEMBL23663384 | 0.87 | THRB (0.47) | POLBKDM4ETHRBTHRAALDH1A1 | |
| SCHEMBL7043080 | 0.84 | POLB (0.51) | POLBKDM4ETHRBTHRAALDH1A1 | |
| SCHEMBL6367633 | 0.84 | THRB (0.50) | POLBKDM4ETHRBTHRAALDH1A1 | |
| SCHEMBL4965112 | 0.83 | GAA (0.47) | POLBKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL23663163 | 0.80 | RAB9A (0.50) | THRBALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL29964937 | 0.80 | RAB9A (0.50) | THRBALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL23663148 | 0.80 | THRB (0.46) | THRBTHRAALDH1A1RORCHPGD | |
| SCHEMBL29965436 | 0.79 | P2RX7 (0.44) | THRBALDH1A1RORCHSD17B10MAPT | |
| SCHEMBL23663365 | 0.78 | THRB (0.43) | KDM4ETHRBTHRAALDH1A1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244037-B | Substituted triazinones as thyroid hormone receptor agonists | 诚益生物(美国)公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-4090652-A1 | SUBSTITUTED TRIAZINONES AS THYROID HORMONE RECEPTOR AGONISTS | Eccogene (Shanghai) Co., Ltd. (CN) | 2022-11-23 | — | — | EP | disclosed |
| CN-115244037-A | Substituted triazinones as thyroid hormone receptor agonists | 上海诚益生物科技有限公司 | 2022-10-25 | — | — | CN | disclosed |