Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 16/20 | 0.39 |
| ▸ | THRA | P10827 | 12/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23663424 | 1.00 | THRB (0.39) | THRBTHRAACLYCYP2C9UGT1A1 | |
| SCHEMBL23671270 | 0.89 | THRB (0.39) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL23663406 | 0.82 | THRB (0.41) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29965366 | 0.82 | THRB (0.40) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL23663347 | 0.82 | THRB (0.40) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL23691581 | 0.81 | THRB (0.40) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL31697986 | 0.81 | ALDH1A1 (0.37) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL23663072 | 0.81 | ALDH1A1 (0.37) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL23671453 | 0.81 | THRA (0.39) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29965311 | 0.81 | THRA (0.39) | THRBTHRACYP2C9UGT1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250320197-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | ECCOGENE INC (US) | 2025-10-16 | — | — | US | disclosed |
| US-12291518-B2 | Thyroid hormone receptor agonists and use thereof | ECCOGENE INC. (US) | 2025-05-06 | — | — | US | disclosed |
| CN-115244037-B | Substituted triazinones as thyroid hormone receptor agonists | 诚益生物(美国)公司 | 2024-10-25 | — | — | CN | disclosed |
| US-11780825-B2 | Thyroid hormone receptor agonists and use thereof | ECCOGENE (SHANGHAI) CO., LTD. (CN) | 2023-10-10 | — | — | US | disclosed |
| EP-4090652-A1 | SUBSTITUTED TRIAZINONES AS THYROID HORMONE RECEPTOR AGONISTS | Eccogene (Shanghai) Co., Ltd. (CN) | 2022-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780825-B2 | Thyroid hormone receptor agonists and use thereof | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885ACLY 4220/4885 |
| US-12291518-B2 | Thyroid hormone receptor agonists and use thereof | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885ACLY 4220/4885 |
| US-20250320197-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885ACLY 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.