Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25691100 | 0.85 | ALDH1A1 (0.56) | MAPTSMN1; SMN2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL21933316 | 0.84 | MAPT (0.50) | MAPTSMN1; SMN2CYP2C19ALDH1A1KMT2A | |
| SCHEMBL29641041 | 0.84 | MAPT (0.50) | MAPTSMN1; SMN2CYP2C19ALDH1A1KMT2A | |
| SCHEMBL30493402 | 0.83 | HTR6 (0.41) | MAPTSMN1; SMN2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL25330396 | 0.83 | HTR6 (0.41) | MAPTSMN1; SMN2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL30195159 | 0.82 | MAPT (0.50) | MAPTSMN1; SMN2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL25330719 | 0.82 | MAPT (0.46) | MAPTSMN1; SMN2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL18300991 | 0.82 | MAPT (0.52) | MAPTSMN1; SMN2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL25330395 | 0.81 | HTR6 (0.44) | MAPTSMN1; SMN2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL30906239 | 0.81 | MAPT (0.47) | MAPTSMN1; SMN2CYP2C19ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022206737-A1 | TETRAHYDRONAPHTHALENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2022-10-06 | — | — | WO | disclosed |