Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18921394 | 1.00 | RIPK1 (0.35) | RIPK1MGLLJAK2JAK1 | |
| SCHEMBL29966475 | 0.91 | RIPK1 (0.34) | RIPK1MGLLJAK2JAK1 | |
| SCHEMBL18921512 | 0.91 | RIPK1 (0.34) | RIPK1MGLLJAK2JAK1 | |
| SCHEMBL18921349 | 0.88 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL20580249 | 0.88 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL18921296 | 0.88 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL18921464 | 0.84 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL18921252 | 0.83 | RIPK1 (0.35) | RIPK1MGLLJAK2JAK1 | |
| SCHEMBL29966499 | 0.83 | MGLL (0.35) | RIPK1MGLL | |
| SCHEMBL28243189 | 0.83 | MGLL (0.35) | RIPK1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602809-B | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1(RIPK 1) | 戴纳立制药公司 | 2022-09-30 | — | — | CN | disclosed |