Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29966499 | 1.00 | MGLL (0.35) | MGLLDDB1CRBNRECQLGPR119 | |
| SCHEMBL29966475 | 0.85 | RIPK1 (0.34) | MGLLRIPK1 | |
| SCHEMBL29966468 | 0.85 | DDB1 (0.36) | DDB1CRBNRECQLGPR119WNT3A | |
| SCHEMBL28873141 | 0.85 | DDB1 (0.36) | DDB1CRBNRECQLGPR119WNT3A | |
| SCHEMBL18921512 | 0.85 | RIPK1 (0.34) | MGLLRIPK1 | |
| SCHEMBL29967034 | 0.85 | DDB1 (0.36) | DDB1CRBNRECQLGPR119WNT3A | |
| SCHEMBL18921529 | 0.85 | DDB1 (0.36) | DDB1CRBNRECQLGPR119WNT3A | |
| SCHEMBL30547503 | 0.84 | DGAT1 (0.39) | DDB1CRBNRECQLGPR119WNT3A | |
| SCHEMBL29048248 | 0.84 | DGAT1 (0.39) | DDB1CRBNRECQLGPR119WNT3A | |
| SCHEMBL29966472 | 0.84 | DGAT1 (0.39) | DDB1CRBNRECQLGPR119WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602809-B | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1(RIPK 1) | 戴纳立制药公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-108602809-A | Inhibitors of isoxazolidine derived receptor interacting protein kinase 1(RIPK 1) | 戴纳立制药公司 | 2018-09-28 | — | — | CN | disclosed |