Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.49 |
| ▸ | BCR | P11274 | 9/20 | 0.49 |
| ▸ | MPL | P40238 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29969463 | 0.99 | ABL1 (0.48) | ABL1BCRMPLGSK3ACDK9 | |
| SCHEMBL29533576 | 0.77 | BTK (0.39) | ABL1BCRPIK3C3 | |
| SCHEMBL23753895 | 0.75 | IGF1R (0.41) | ABL1BCRSCN9AIGF1R | |
| SCHEMBL26172196 | 0.75 | BRAF (0.39) | ABL1BCRIGF1R | |
| SCHEMBL16996884 | 0.74 | GSK3A (0.48) | MPLGSK3ACDK9CDK5TAOK1 | |
| SCHEMBL25211019 | 0.74 | KDR (0.40) | ABL1BCRSCN9AIGF1R | |
| SCHEMBL23763117 | 0.74 | RXRA (0.43) | ABL1BCRIGF1R | |
| SCHEMBL23762957 | 0.73 | KCNN3 (0.36) | ABL1BCRSCN9AIGF1R | |
| SCHEMBL29967969 | 0.73 | KCNN3 (0.36) | ABL1BCRSCN9AIGF1R | |
| SCHEMBL26172595 | 0.73 | IGF1R (0.44) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151534-B | Inhibitors of interleukin-1 receptor associated kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof and methods of use thereof | 南京药石科技股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115151534-A | Inhibitors of interleukin-1 receptor-related kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2022-10-04 | — | — | CN | disclosed |