Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.40 |
| ▸ | BRAF | P15056 | 9/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23763117 | 0.82 | RXRA (0.43) | KDRBRAFGPR3ABL1BCR | |
| SCHEMBL25201725 | 0.79 | ROCK1 (0.44) | NPC1RAB9AGAAALOX15ABL1 | |
| SCHEMBL26548751 | 0.78 | MAPK14 (0.40) | KDRBRAFCYP1A2IGF1RHRH4 | |
| SCHEMBL23213851 | 0.77 | KDR (0.49) | KDRBRAFSMN1; SMN2 | |
| SCHEMBL25524510 | 0.76 | KDR (0.39) | KDRBRAFGAASMN1; SMN2ABL1 | |
| SCHEMBL30001628 | 0.76 | NOS3 (0.57) | KDR | |
| SCHEMBL2570584 | 0.76 | NOS3 (0.57) | KDR | |
| SCHEMBL29969144 | 0.76 | NOS3 (0.57) | SCN5ASCN9AKCNH2NPC1RAB9A | |
| SCHEMBL23213556 | 0.76 | NOS3 (0.57) | SCN5ASCN9AKCNH2NPC1RAB9A | |
| SCHEMBL29968592 | 0.74 | ABL1 (0.49) | SCN9AABL1BCRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |