Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29970857 | 0.85 | TSHR (0.43) | POLBPTGS2LMNAMAPTKMT2A | |
| SCHEMBL3500290 | 0.78 | LMNA (0.61) | POLBPTGS2LMNAHTTMAPT | |
| SCHEMBL27776226 | 0.73 | LMNA (0.81) | POLBPTGS2LMNAHTTMAPT | |
| SCHEMBL31086767 | 0.70 | LMNA (0.68) | POLBPTGS2LMNAHTTMAPT | |
| SCHEMBL29345081 | 0.70 | CTSL (0.71) | POLBPTGS2LMNAHTTMAPT | |
| SCHEMBL14866255 | 0.69 | POLB (0.51) | POLBPTGS2LMNAHTTKMT2A | |
| SCHEMBL23321312 | 0.69 | LMNA (0.82) | POLBPTGS2LMNAHTTMAPT | |
| SCHEMBL23326428 | 0.69 | PTGS2 (0.68) | POLBPTGS2LMNAHTTMAPT | |
| SCHEMBL1658390 | 0.69 | MAPT (0.82) | PTGS2LMNAHTTMAPTKMT2A | |
| SCHEMBL28455338 | 0.67 | USP2 (0.75) | POLBLMNAHTTMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022242321-A1 | PI3Kα SELECTIVE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 中国药科大学 | 2022-11-24 | — | — | WO | disclosed |