SCHEMBL29972906

SCHEMBL29972906

CC(C)CNc1nc(N)c(F)c(-c2cc[nH]n2)n1

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.40
ESR1 P03372 10/20 0.37
ESR2 Q92731 1/20 0.36
MAPT P10636 1/20 0.35
HRH4 Q9H3N8 3/20 0.34
KMT2A Q03164 2/20 0.33
ALOX5AP P20292 1/20 0.32
FEN1 P39748 1/20 0.32
MEN1 O00255 1/20 0.32
MAP4K4 O95819 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29972355 0.86 PKM (0.37)
SCHEMBL29973291 0.81 NOS1 (0.33)
SCHEMBL29972979 0.73
SCHEMBL29972741 0.70 GAA (0.35) MAPTKMT2A
SCHEMBL16664957 0.64 HRH4 (0.44) ESR1ESR2HRH4
SCHEMBL7171629 0.63 ESR1 (0.46) ESR1ESR2HRH4
SCHEMBL9061566 0.61 ESR1 (0.55) IDH1ESR1ESR2HRH4KMT2A
SCHEMBL29972663 0.61 PDPK1 (0.40) KMT2AMEN1
SCHEMBL16146292 0.61 ESR1 (0.44) IDH1ESR1ESR2MAPTHRH4
SCHEMBL16146295 0.60 PDPK1 (0.50) IDH1ESR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115381832-A Treatment of cancer 深圳明赛瑞霖药业有限公司 2022-11-25 CN disclosed