SCHEMBL29973291

SCHEMBL29973291

CNc1nc(N)c(F)c(-c2cc[nH]n2)n1

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 1/20 0.33
PDPK1 O15530 1/20 0.31
SCN9A Q15858 1/20 0.31
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
CA9 Q16790 2/20 0.31
CA12 O43570 1/20 0.31
CA3 P07451 1/20 0.31
CA4 P22748 1/20 0.31
CA6 P23280 1/20 0.31
CA5A P35218 1/20 0.31
CA7 P43166 1/20 0.31
CA13 Q8N1Q1 1/20 0.31
CA14 Q9ULX7 1/20 0.31
ADORA1 P30542 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29972355 0.85 PKM (0.37) PDPK1CA1CA2CA9ADORA1
SCHEMBL29972906 0.81 IDH1 (0.40)
SCHEMBL29972979 0.80
SCHEMBL29972741 0.77 GAA (0.35) PDPK1
SCHEMBL23019360 0.66 KDR (0.41) ADORA1
SCHEMBL2745624 0.64 TLR8 (0.33) NOS1
SCHEMBL28875448 0.63 TRPA1 (0.31)
SCHEMBL20161346 0.62 TGFBR1 (0.34)
SCHEMBL20090330 0.60 IDH1 (0.31)
SCHEMBL30927740 0.60 ULK1 (0.43) ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115381832-A Treatment of cancer 深圳明赛瑞霖药业有限公司 2022-11-25 CN disclosed