Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 10/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11470591 | 0.87 | KDM4E (0.59) | KDM4EFGFR1USP5SMN1; SMN2 | |
| SCHEMBL11472894 | 0.74 | KDM4E (0.62) | KDM4EFGFR1USP5SMN1; SMN2 | |
| SCHEMBL363828 | 0.73 | KDM4E (1.00) | KDM4ESMN1; SMN2 | |
| SCHEMBL38657620 | 0.68 | KDM4E (0.43) | KDM4EGRM2USP5SMN1; SMN2 | |
| SCHEMBL29974345 | 0.65 | KDM4E (0.54) | KDM4EFGFR1 | |
| SCHEMBL361719 | 0.65 | KDM4E (0.54) | KDM4EFGFR1 | |
| SCHEMBL15652101 | 0.65 | NPC1 (0.55) | KDM4ESMN1; SMN2 | |
| SCHEMBL19659562 | 0.65 | PARP1 (0.48) | KDM4EGRM2PLA2G10 | |
| SCHEMBL19659747 | 0.63 | GRM2 (0.44) | GRM2 | |
| SCHEMBL29967853 | 0.63 | KDM4E (0.51) | KDM4EUSP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307067-B1 | AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME LLC (US) | 2022-11-02 | — | — | EP | claimed |