Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | CD38 | P28907 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175638 | 1.00 | PBRM1 (0.49) | PBRM1KDM4EALDH1A1LMNAKAT6A | |
| SCHEMBL27214503 | 0.84 | ALDH1A1 (0.52) | KDM4EALDH1A1KMT2ATSHRCES2 | |
| SCHEMBL27919384 | 0.83 | PARP1 (0.50) | PBRM1KDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL27710545 | 0.83 | KEAP1 (0.49) | PBRM1KDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL29454770 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KAT6AKMT2ATSHRCES2 | |
| SCHEMBL401838 | 0.81 | TSHR (0.63) | PBRM1KDM4EALDH1A1LMNAKAT6A | |
| SCHEMBL30462062 | 0.81 | TSHR (0.63) | PBRM1KDM4EALDH1A1LMNAKAT6A | |
| SCHEMBL9693738 | 0.81 | KAT6A (0.47) | ALDH1A1KAT6AKMT2ATSHRCES2 | |
| SCHEMBL413285 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KAT6AKMT2ATSHRCES2 | |
| Hydrochloric Acid SCHEMBL10557491 | 0.79 | TSHR (0.61) | PBRM1KDM4EALDH1A1LMNAKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329757-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022232331-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-11-03 | — | — | WO | disclosed |