Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19028071 | 1.00 | GAA (0.32) | GAANQO2ADORA2AADORA2BTDP1 | |
| SCHEMBL31235372 | 0.77 | — | — | |
| SCHEMBL21223482 | 0.77 | NOS3 (0.38) | NOS3NOS1NOS2 | |
| SCHEMBL30915338 | 0.77 | NOS3 (0.38) | NOS3NOS1NOS2 | |
| SCHEMBL29344249 | 0.77 | NOS2 (0.37) | NOS3NOS1NOS2 | |
| SCHEMBL28018242 | 0.77 | ALDH1A1 (0.46) | GAANQO2ADORA2AADORA2BTDP1 | |
| SCHEMBL28729594 | 0.75 | CYP3A4 (0.36) | GAANQO2ADORA2AADORA2BTDP1 | |
| SCHEMBL22029038 | 0.73 | NOS2 (0.37) | NOS3NOS1NOS2 | |
| SCHEMBL19785603 | 0.71 | TDP1 (0.34) | TDP1NOS3NOS1NOS2MAPT | |
| SCHEMBL26608375 | 0.71 | ALDH1A1 (0.41) | GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329757-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| CN-117561063-A | Heterocyclic compounds and methods of use | 安进公司 | 2024-02-13 | — | — | CN | disclosed |
| WO-2022232331-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-11-03 | — | — | WO | disclosed |