Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28515732 | 0.89 | ALDH1A1 (0.50) | ALDH1A1CYP2D6ATMPOLBPIK3CA | |
| SCHEMBL16668538 | 0.82 | ALDH1A1 (0.43) | ALDH1A1CYP2D6ATMPOLBPIK3CA | |
| SCHEMBL28996034 | 0.78 | ALDH1A1 (0.56) | ALDH1A1CYP2D6ATMPOLBLMNA | |
| SCHEMBL29687392 | 0.78 | ALDH1A1 (0.56) | ALDH1A1CYP2D6ATMPOLBLMNA | |
| SCHEMBL29433996 | 0.77 | ALDH1A1 (0.58) | ALDH1A1CYP2D6ATMPOLBLMNA | |
| SCHEMBL28729752 | 0.77 | ALDH1A1 (0.58) | ALDH1A1CYP2D6ATMPOLBLMNA | |
| SCHEMBL30998660 | 0.76 | ALDH1A1 (0.48) | ALDH1A1CYP2D6ATMPOLBLMNA | |
| Ammonia Solution, Strong SCHEMBL26694782 | 0.76 | ALDH1A1 (0.43) | ALDH1A1CYP2D6ATMPOLBPIK3CA | |
| SCHEMBL29937376 | 0.75 | ALDH1A1 (0.56) | ALDH1A1CYP2D6ATMPOLBLMNA | |
| Hydrochloric Acid SCHEMBL7522555 | 0.74 | ALDH1A1 (0.68) | ALDH1A1CYP2D6ATMPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329757-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022232331-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-11-03 | — | — | WO | disclosed |