Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 9/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.39 |
| ▸ | INSR | P06213 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23153875 | 1.00 | EGFR (0.42) | EGFRIGF1RALKINSRMEN1 | |
| SCHEMBL23154090 | 0.89 | INSR (0.49) | EGFRIGF1RALKINSRCDK7 | |
| SCHEMBL23153748 | 0.88 | EGFR (0.41) | EGFRIGF1RALKINSRMEN1 | |
| SCHEMBL23154179 | 0.88 | ALK (0.40) | EGFRIGF1RALKINSRCDK7 | |
| SCHEMBL23154176 | 0.87 | MEN1 (0.36) | EGFRIGF1RALKINSRMEN1 | |
| SCHEMBL23153853 | 0.87 | EGFR (0.40) | EGFRIGF1RALKINSRMEN1 | |
| SCHEMBL23153842 | 0.87 | EGFR (0.38) | EGFRIGF1RALKINSRMEN1 | |
| SCHEMBL23154188 | 0.87 | RAF1 (0.38) | EGFRIGF1RALKINSRMEN1 | |
| SCHEMBL23153854 | 0.86 | EGFR (0.39) | EGFRIGF1RALKINSRMEN1 | |
| SCHEMBL30741194 | 0.86 | EGFR (0.39) | EGFRIGF1RALKINSRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117425646-A | Phosphono derivative, composition thereof and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-01-19 | — | — | CN | disclosed |
| WO-2022228547-A1 | PHOSPHONYL DERIVATIVE, AND COMPOSITION AND PHARMACEUTICAL APPLICATION THEREOF | 四川海思科制药有限公司 | 2022-11-03 | — | — | WO | disclosed |