SCHEMBL29978545

SCHEMBL29978545

O=C(COc1cccc(Cl)c1)N1CCc2sc(-c3noc(C(F)(F)F)n3)cc2C1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 1/20 0.46
HDAC6 Q9UBN7 5/20 0.43
HDAC1 Q13547 3/20 0.43
HDAC5 Q9UQL6 2/20 0.43
HDAC8 Q9BY41 2/20 0.43
MAPT P10636 2/20 0.42
ENPP2 Q13822 4/20 0.41
F2 P00734 1/20 0.39
TPSAB1 Q15661 1/20 0.39
TPSD1 Q9BZJ3 1/20 0.39
TPSG1 Q9NRR2 1/20 0.39
MC4R P32245 1/20 0.39
MCHR1 Q99705 1/20 0.39
HDAC4 P56524 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
CGAS Q8N884 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29978563 0.92 HDAC6 (0.43) HDAC6HDAC1HDAC5HDAC8ENPP2
SCHEMBL29978322 0.92 HDAC6 (0.43) FKBP1AHDAC6HDAC1HDAC5HDAC8
SCHEMBL29978512 0.91 GAA (0.46) HDAC6HDAC1HDAC5HDAC8MAPT
SCHEMBL29978400 0.91 HDAC6 (0.45) HDAC6HDAC1HDAC5HDAC8MAPT
SCHEMBL29977854 0.89 HDAC6 (0.41) HDAC6HDAC1HDAC5HDAC8F2
SCHEMBL29978171 0.89 HDAC6 (0.44) HDAC6HDAC1HDAC5HDAC8F2
SCHEMBL29978074 0.88 L3MBTL1 (0.49) FKBP1AHDAC6HDAC1HDAC5HDAC8
SCHEMBL29978374 0.87 RAB9A (0.43) HDAC6HDAC1HDAC5HDAC8MC4R
SCHEMBL29978317 0.87 HDAC6 (0.44) FKBP1AHDAC6HDAC1HDAC5HDAC8
SCHEMBL29977782 0.87 HDAC6 (0.41) HDAC6HDAC1HDAC5HDAC8HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO claimed
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO disclosed