SCHEMBL29978374

SCHEMBL29978374

O=C(COc1ccccc1Cl)N1CCc2sc(-c3noc(C(F)(F)F)n3)cc2C1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.43
HDAC1 Q13547 2/20 0.43
HDAC8 Q9BY41 2/20 0.43
HDAC6 Q9UBN7 2/20 0.43
HDAC5 Q9UQL6 1/20 0.43
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
POLB P06746 2/20 0.42
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
HTT P42858 2/20 0.40
HPGD P15428 2/20 0.40
HSD17B10 Q99714 1/20 0.40
TSHR P16473 1/20 0.39
TP53 P04637 1/20 0.39
NOTUM Q6P988 1/20 0.39
NPC1 O15118 1/20 0.39
MC4R P32245 1/20 0.38
PARP1 P09874 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29977961 0.92 ALDH1A1 (0.44) RAB9AHDAC1HDAC8HDAC6HDAC5
SCHEMBL29977850 0.91 HDAC6 (0.44) HDAC1HDAC8HDAC6HDAC5MEN1
SCHEMBL29978447 0.91 HDAC6 (0.44) RAB9AHDAC1HDAC8HDAC6HDAC5
SCHEMBL29978099 0.90 MEN1 (0.52) RAB9AHDAC1HDAC8HDAC6HDAC5
SCHEMBL29977782 0.88 HDAC6 (0.41) RAB9AHDAC1HDAC8HDAC6HDAC5
SCHEMBL29978262 0.88 HDAC6 (0.42) RAB9AHDAC1HDAC8HDAC6HDAC5
SCHEMBL29978400 0.88 HDAC6 (0.45) RAB9AHDAC1HDAC8HDAC6HDAC5
SCHEMBL29978734 0.88 HDAC6 (0.39) HDAC1HDAC8HDAC6HDAC5
SCHEMBL29978545 0.87 FKBP1A (0.46) HDAC1HDAC8HDAC6HDAC5L3MBTL1
SCHEMBL29978322 0.87 HDAC6 (0.43) HDAC1HDAC8HDAC6HDAC5MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO claimed
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO disclosed