Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.79 |
| ▸ | KDM4A | O75164 | 1/20 | 0.79 |
| ▸ | KDM4B | O94953 | 1/20 | 0.79 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.66 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657817 | 0.87 | ADORA3 (0.72) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL17716927 | 0.87 | ALDH1A1 (0.75) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL18997288 | 0.87 | ADORA3 (0.82) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL13209246 | 0.85 | ADORA3 (0.70) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL19783013 | 0.84 | ADORA3 (0.78) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL19974299 | 0.84 | ADORA3 (0.68) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL31361484 | 0.84 | ADORA3 (0.90) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL19974298 | 0.84 | ADORA3 (0.68) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL11786433 | 0.83 | ALDH1A1 (0.68) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 | |
| SCHEMBL21241884 | 0.83 | ALDH1A1 (0.68) | ADORA3KDM4AKDM4BKDM5BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197699-A1 | I-OXA-3-Azaspiro (4.5) Decan-2-One And 1-OXA-3, 8-Diazaspiro (4.5) Decan-2-One Derivatives For The Treatment of Eating Disorders | GLAXO GROUP LIMITED | 2010-08-05 | — | — | US | disclosed |
| EP-2121673-A1 | I-OXA-3-AZASPIRO (4.5) DECAN-2-ONE AND 1-OXA-3, 8-DIAZASPIRO (4.5) DECAN-2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS | Glaxo Group Limited (GB) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008092887-A1 | I-OXA-3-AZASPIRO (4.5) DECAN-2-ONE AND 1-OXA-3, 8-DIAZASPIRO (4.5) DECAN-2-ONE DERIVATIVES FOR THE TREATMENT OF EATING DISORDERS | GLAXO GROUP LIMITED (GB) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197699-A1 | I-OXA-3-Azaspiro (4.5) Decan-2-One And 1-OXA-3, 8-Diazaspiro (4.5) Decan-2-One Derivatives For The Treatment of Eating Disorders | NPY5R, NPY1R, NPY4R | ADORA3 546/4885KDM4A 707/4885KDM4B 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.