Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29701288 | 0.98 | HPGD (0.54) | HPGDXBP1MAPTALDH1A1HSD17B10 | |
| SCHEMBL11333663 | 0.88 | LMNA (0.56) | HPGDXBP1MAPTALDH1A1HSD17B10 | |
| SCHEMBL4335276 | 0.87 | ALDH1A1 (0.45) | HPGDXBP1MAPTALDH1A1HSD17B10 | |
| SCHEMBL235783 | 0.84 | ALDH1A1 (0.55) | HPGDMAPTALDH1A1HSD17B10TSHR | |
| Bicarbonate SCHEMBL29983911 | 0.83 | ESR1 (0.61) | HPGDXBP1MAPTALDH1A1HSD17B10 | |
| Benzene SCHEMBL28043964 | 0.83 | ALDH1A1 (0.57) | HPGDALDH1A1HSD17B10TSHRKMT2A | |
| Bicarbonate SCHEMBL236893 | 0.83 | ALDH1A1 (0.57) | HPGDALDH1A1HSD17B10TSHRKMT2A | |
| Bicarbonate SCHEMBL20694841 | 0.83 | ALDH1A1 (0.57) | HPGDALDH1A1HSD17B10TSHRKMT2A | |
| Bicarbonate SCHEMBL29943829 | 0.83 | ALDH1A1 (0.57) | HPGDALDH1A1HSD17B10TSHRKMT2A | |
| SCHEMBL538561 | 0.81 | ESR1 (0.63) | HPGDXBP1MAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112654508-B | Improved method for locally coloring plastic parts | 科思创知识产权两合公司 | 2022-11-08 | — | — | CN | disclosed |