Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL11325831 | 0.91 | LMNA (0.50) | ALDH1A1LMNAEPHX2GABRR1EPHX1 | |
| Succinic Acid SCHEMBL28203534 | 0.89 | LMNA (0.56) | ALDH1A1LMNAEGLN1ALKBH5SUCNR1 | |
| Azelaic Acid SCHEMBL29061132 | 0.89 | TSHR (0.52) | ALDH1A1LMNAEPHX2EPHX1PHF8 | |
| Sebacic Acid SCHEMBL29061112 | 0.89 | TSHR (0.52) | ALDH1A1LMNAEPHX2EPHX1PHF8 | |
| Succinic Acid SCHEMBL30785609 | 0.87 | LMNA (0.47) | ALDH1A1LMNAEGLN1ALKBH5SUCNR1 | |
| Cyclohexylamine SCHEMBL11187361 | 0.85 | LDHA (0.45) | ALDH1A1MMP8MMP1EPHX2MMP2 | |
| Cyclopentanamine SCHEMBL29155695 | 0.85 | FFAR3 (0.50) | ALDH1A1LMNAMMP8MMP1MMP2 | |
| Cyclohexylamine SCHEMBL7853875 | 0.85 | FFAR3 (0.50) | ALDH1A1LMNAMMP8MMP1MMP2 | |
| Cyclohexylamine SCHEMBL27975474 | 0.85 | GLRA1 (0.50) | ALDH1A1LMNAMMP8MMP1MMP2 | |
| Cyclohexylamine SCHEMBL578785 | 0.84 | CES2 (0.43) | ALDH1A1MMP8MMP1EPHX2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024034516-A1 | ELECTROCONDUCTIVE PASTE AND CONNECTION STRUCTURE | 積水化学工業株式会社 | 2024-02-15 | — | — | WO | disclosed |
| US-20100197841-A1 | HYDROXY ACID AMINE SALT, METHOD FOR PRODUCING THE SAME, AND RUBBER COMPOSITION CONTAINING THE SAME | THE YOKOHAMA RUBBER CO., LTD. | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197841-A1 | HYDROXY ACID AMINE SALT, METHOD FOR PRODUCING THE SAME, AND RUBBER COMPOSITION CONTAINING THE SAME | HRH3, HRH2, HRH4 | ALDH1A1 765/4885LMNA 552/4885EGLN1 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.