Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24815798 | 1.00 | NAMPT (0.42) | NAMPTHDAC8HDAC6TP53ACACB | |
| SCHEMBL24814391 | 0.86 | RYR2 (0.43) | NAMPTTP53ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL26845908 | 0.84 | DPP8 (0.40) | NAMPTTP53ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL29987551 | 0.83 | MAOB (0.39) | NAMPTSMN1; SMN2 | |
| SCHEMBL24817127 | 0.82 | MAOB (0.40) | NAMPTHDAC8ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL24817122 | 0.82 | NAMPT (0.44) | NAMPT | |
| SCHEMBL29986905 | 0.81 | SMN1; SMN2 (0.42) | NAMPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL24815669 | 0.81 | SMN1; SMN2 (0.42) | NAMPTALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL24815670 | 0.79 | NLRP3 (0.35) | ALDH1A1KMT2ASMN1; SMN2MAPK1NPC1 | |
| SCHEMBL24814740 | 0.79 | NLRP3 (0.35) | NAMPTSMN1; SMN2RAB9ANPC1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022251343-A2 | CDGSH IRON SULFUR DOMAIN 2 ACTIVATORS AND USE THEREOF | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2022-12-01 | — | — | WO | disclosed |