Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.34 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987551 | 0.87 | MAOB (0.39) | NAMPTSMN1; SMN2HSP90AA1LMNA | |
| SCHEMBL24814391 | 0.87 | RYR2 (0.43) | ALDH1A1NAMPTSMN1; SMN2HSP90AA1TP53 | |
| SCHEMBL24817122 | 0.86 | NAMPT (0.44) | DPP8DPP9DPP7NAMPTDPP4 | |
| SCHEMBL24817127 | 0.86 | MAOB (0.40) | ALDH1A1HSD17B10NAMPTSMN1; SMN2MEN1 | |
| SCHEMBL24815669 | 0.86 | SMN1; SMN2 (0.42) | ALDH1A1NAMPTSMN1; SMN2POLBLMNA | |
| SCHEMBL29986905 | 0.86 | SMN1; SMN2 (0.42) | ALDH1A1NAMPTSMN1; SMN2POLBLMNA | |
| SCHEMBL29987611 | 0.84 | NAMPT (0.42) | ALDH1A1NAMPTSMN1; SMN2POLBTP53 | |
| SCHEMBL24815798 | 0.84 | NAMPT (0.42) | ALDH1A1NAMPTSMN1; SMN2POLBTP53 | |
| SCHEMBL24815670 | 0.83 | NLRP3 (0.35) | ALDH1A1HSD17B10SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24814740 | 0.83 | NLRP3 (0.35) | DPP8DPP9NAMPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827629-B2 | CDGSH iron sulfur domain 2 activators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2023-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827629-B2 | CDGSH iron sulfur domain 2 activators and use thereof | CISD2, CISD1, FECH | DPP8 4457/4885DPP9 4490/4885DPP7 4414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.