Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PGK1 | P00558 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27087788 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25008186 | 0.97 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25008208 | 0.88 | ULK1 (0.58) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL22672870 | 0.87 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25008387 | 0.87 | ULK1 (0.44) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1917052 | 0.85 | ALDH1A1 (0.54) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3337053 | 0.85 | ALDH1A1 (0.54) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3283074 | 0.84 | STK17A (0.64) | SMN1; SMN2ALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL1917842 | 0.84 | PRKCQ (0.52) | SMN1; SMN2HTTULK1ULK2IRAK4 | |
| SCHEMBL25008207 | 0.84 | ULK1 (0.40) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320121-A2 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES AS ULK1/2 INHIBITORS AND THEIR USE THEREOF | LifeArc (GB) | 2024-02-14 | — | — | EP | disclosed |
| CN-117545751-A | 2, 4-diaminopyrimidine derivatives as ULK1/2 inhibitors and their use | 生命爱科 | 2024-02-09 | — | — | CN | disclosed |
| WO-2022214869-A2 | ULK1/2 INHIBITORS AND THEIR USE THEREOF | LIFEARC (GB) | 2022-10-13 | — | — | WO | disclosed |