Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29989339 | 0.87 | SMN1; SMN2 (0.51) | ULK1ULK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL27087788 | 0.87 | SMN1; SMN2 (0.51) | ULK1ULK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL22648377 | 0.87 | ALDH1A1 (0.41) | ULK1ULK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL25008207 | 0.86 | ULK1 (0.40) | ULK1ULK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL25008186 | 0.86 | SMN1; SMN2 (0.48) | ULK1ULK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL22648392 | 0.86 | ULK1 (0.46) | ULK1ULK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL25008208 | 0.85 | ULK1 (0.58) | ULK1ULK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL22648395 | 0.85 | ALDH1A1 (0.38) | SMN1; SMN2HTTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL22648425 | 0.84 | ULK1 (0.43) | ULK1ULK2SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL22648266 | 0.82 | TBK1 (0.41) | ULK1ULK2SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039712-A1 | PHENYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230039712-A1 | PHENYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | BECN1, SQSTM1, ATG7 | ULK1 4/4885ULK2 9/4885SMN1; SMN2 3477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.